|Place of Origin:||CHINA|
|Minimum Order Quantity:||5000 Boxes|
|Packaging Details:||10 tablets/blister,10 blisters/box,200 boxes/carton|
|Delivery Time:||40 days|
|Payment Terms:||L/C, D/A, D/P, T/T, Western Union, MoneyGram|
|Supply Ability:||10000 boxes/month|
|Application:||Oral Administration||Group:||Alimentary Tract And Metabolism|
|Pharmaceutical Form:||White, Biconvex, Round, Film-coated Tablets||Therapeutic Indications:||Treatment Of Type 2 Diabetes Mellitus|
|Shelf Life:||3 Years||Special Precautions For Storage:||Do Not Store Above 25°C.|
GMP certified Metformin 500mg film-coated tablets antihyperglycaemic drugs treatment for type 2 diabetes mellitus
1 film-coated tablet contains:
Metformin hydrochloride 500 mg
Metformin is a type of oral medication used to treat type 2 diabetes .
Metformin is taken in pill-form. It is generally taken twice per day, at breakfast and at dinner. For those with higher levels of insulin resistance, your doctor may prescribe metformin to be taken at all three meals: breakfast, lunch, and dinner.
• Treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control.
• In adults, Metformin film-coated tablets may be used as monotherapy or in combination with other oral anti-diabetic agents or with insulin.
• In children from 10 years of age and adolescents, Metformin film-coated tablets may be used as monotherapy or in combination with insulin.
A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure.
Posology and method of administration
Monotherapy and combination with other oral antidiabetic agents:
• The usual starting dose is one tablet 2 or 3 times daily given during or after meals.
• After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. The maximum recommended dose of metformin is 3 g daily.
• If transfer from another oral antidiabetic agent is intended: discontinue the other agent and initiate metformin at the dose indicated above.
Combination with insulin
Metformin and insulin may be used in combination therapy to achieve better blood glucose control. Metformin is given at the usual starting dose of one tablet 2-3 times daily, while insulin dosage is adjusted on the basis of blood glucose measurements.
Elderly: due to the potential for decreased renal function in elderly subjects, the metformin dosage should be adjusted based on renal function. Regular assessment of renal function is necessary (see section 4.4 “Special warnings and precautions for use”).
Children and adolescents
Monotherapy and combination with insulin:
• Metformin film-coated tablets can be used in children from 10 years of age and adolescents.
• The usual starting dose is one tablet of 500 mg or 850 mg once daily, given during meals or after meals.
• After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. The maximum recommended dose of metformin is 2 g daily, taken as 2 or 3 divided doses.
• Hypersensitivity to metformin hydrochloride or to any of the other excipients
• Diabetic ketoacidosis, diabetic pre-coma
• Renal failure or renal dysfunction (e.g., serum creatinine levels > 135 μmol/L in males and > 110 μmol/L in females)
• Acute conditions with the potential to alter renal function such as:
- severe infection
• Intravascular administration of iodinated contrast agents (see 4.4 “Special warnings and precautions for use”)
• Acute or chronic disease which may cause tissue hypoxia such as:
- cardiac or respiratory failure
- recent myocardial infarction
• Hepatic insufficiency, acute alcohol intoxication, alcoholism